群体感应系统通过释放到环境中的信号分子来进行交流,进而协调群体行为,因其结构简单、机理清晰而广泛应用于合成生物学的研究.简要介绍合成生物学的概念,着重阐述基于群体感应系统的合成生物学研究及其在细胞浓度控制、生物被膜信号通路和生物化工领域的应用.最后,探讨群体感应系统研究的不足,并做进一步展望.
Quorum-sensing system coordinates bacterium behaviour via the secretion of specific signaling molecules in a population density-dependent manner. This system is widely used in synthetic biology because of its simple structure and clear mechanism In this article, the concept of synthetic biology is introduced briefly. This article mainly focuses on synthetic biology basing on quorum-sensing system and its applications in fields of cell density control, biofilm signal pathways and biochemical industry. Finally, limition of study on quorum-sensing system is discussed. And the prospect of future development is presented.