目的:探讨急性右心室梗死(ARVI)临床和血流动力学特征以及扩容与再灌注治疗效果。 方法:观察58例ARVI患者的临床经过,根据有创血流动力学特征分为1型(n=28)、2型(n=19)、3型(n=11)共三型,根据是否行再灌注治疗分为一般治疗组(n=29)及再灌注治疗组(n=29),评估扩容及再灌注治疗的疗效。以发病2周及4周的存活率或病死率和心脏超声右心室运动评分为观察指标。 结果:血流动力学1、2、3三型的病死率分别为:3.5%,26%,54%,其中2型多为严重ARVI,常常伴严重低血压休克,预后较差;3型除ARVI外,左心室梗死程度重,治疗效果差。1、2型患者对扩容效果好。所有患者在再灌注治疗组存活86%,右心室超声评分改善1.2;一般治疗组存活72%,右心室超声评分改善0.4,两组比较差异显著(P〈0.05)。 结论:ARVI血流动力学特征检测有助于病情评估和治疗选择。再灌注治疗可明显提高患者心肌功能的恢复,降低病死率。
Objective: To investigate the hemodynamic characteristics of acute right ventricular infarction and to determine whether the volume-expansion and reperfusion administration improve the clinical outcomes and survival after acute right ventricular infarction. Methods: We observed the clinical outcomes of 58 patients with acute right ventricular infarction. According to the hemodynamic characteristics, the patients were divided into three types ; and according to treatment strategy, the patients were divided into common treatment group and reperfusion treatment group. The effects of volume-expansion and reperfusion administration were analyzed on survival or mortality at 2 and 4 weeks after the attack. The right ventricular function was studied by echocardiography. Results: The mortality of each type was 3.5% ,26% or 54%, respectively. Most patients in type 2 had severe right ventricular infarction and severe hypotension shock ; while in type 3, the patients with severely damaged right and left ventricular function had a higher mortality rate. In patients on reperfusion treatment, the survival was 86% at the end of the 2^nd week, and the right ventricular function score was improved by 1.2. In patients on common treatment, the survival was 72% and the right ventricular function score was improved by 0.4, both having significant differences. Conclusion: The detection of hemodynamic characteristics is helpful for the evaluation and treatment strategy in patients with right ventricular infarction. Reperfusion treatment can improve right ventricular function and decrease mortality.