中文摘要：

目的观察吉非罗齐（gemfibrozil,Gem）对实验性2型糖尿病（type 2 diabetes mellitus,T2DM）大鼠的降糖、降脂作用及其可能机制。方法采用高糖高脂膳食4周诱导大鼠胰岛素抵抗后,腹腔注射亚致病剂量链脲佐菌素（streptozotocin,STZ）的方法制备T2DM模型,并观察Gem对其血脂、血糖代谢的影响及其可能机制。结果连续灌胃给药8周后,Gem显著降低实验性糖尿病大鼠的空腹血糖（fasting blood glucose,FBG）和三酰甘油（triglyceride,TG）、总胆固醇（totalcholesterol,TC）、低密度脂蛋白胆固醇（low-density lipoprotein cholesterol,LDL-C）及游离脂肪酸含量（nonesterified fatty acid,NEFA）（P〈0.05或P〈0.01）,显著增高实验性糖尿病大鼠血清SOD活力（superoxide dismutase,SOD）,降低模型组大鼠MDA（maleic dialdehyde,MDA）含量（P〈0.05或P〈0.01）。结论Gem不仅对实验性T2DM大鼠血脂具有良好的调节作用,还能改善实验性T2DM大鼠的血糖代谢,显著降低FBG。

英文摘要：

OBJECTIVE To investigate the antidiabetic effect of gemfibrozil （Gem） and its possible mechanisms in experimental type 2 diabetes mellitus （T2DM） of rat. METHODS Experimental model of diabetes mellitus was induced by intraperitoneally injection of streptozotocin （STZ） in rats after feeding high fat and sucrose food for 4 weeks. RESULTS After 8 week＇ s oral-administration, the level of fasting blood glucose （FBG）, serum concentration of triglyceride （TG）, total cholesterol （TC）, low-density lipoprotein cholesterol （LDL-C） and nonesterified fatty acid （NEFA） were decreased significantly in Gem treated groups compared with T2DM model group. Superoxide dismutase （SOD） activity was increased signifcantly in Gem groups compared with T2DM model group and malondialdehyde （MDA） content was decreased significantly in Gem groups compared with T2DM model group. CONCLUSION Gem can not only decrease hyperlipidemia but also improve glycometabolism by decreasing FBG in T2DM rat.