以D-甘露醇转化得到的骨架为支架Pauson-Khand反应成功实现了高度区域和立体选择性地合成具有C2对称性的多官能团的多环手性化合物1,并采用核磁共振和X单晶衍射等分析方法对化合物1的结构进行了讨论.
The enantiopure C2-symmetric polycyclic compound 1 with multiple functional groups was synthesized efficiently using a two-directional regio- and stereoselective intramolecular Pauson-Khand reaction upon the precursor derived from D-mannitol. The full target structure was established and confirmed by the corresponding NMR and X-ray crystallography studies.