中文摘要：

内皮细胞激活、损伤、凋亡时,会向细胞外释放内皮微粒,其作为反映内皮细胞功能的新型标记物,在多种病理状态时都有增加。糖尿病心肌病的病理过程中,内皮损伤、血管再生、氧化应激与炎症反应以及肾素血管紧张素系统激活等过程都与内皮微粒存在紧密联系。

英文摘要：

Endothelial microparticles（EMPs） are small membrane vesicles that shed from the surface of endothelial cells in response to activation or apoptosis.As a new marker of endothelial cell function,increased levels of EMP have been documented in several diseases.The pathogenesis of diabetic cardiomyopathy was associated with persistence of endothelial dysfunction,angiogenesis,oxidative stress,and inflammation.The activation of the renin-angiotensin system also involves EMPs.