中文摘要：

胆酸盐外排泵是肝细胞分泌胆酸盐进入胆汁的主要转运体,其变异和功能抑制与许多胆汁淤积症和药致肝损伤有关。对这些疾病的分析总结加深了我们对胆酸盐外排泵（bile salt export pump,BSEP）生理和病理功能的认识,该文将对BSEP的结构、表达调控、底物及抑制剂,及其相关疾病进行简要综述,以期为临床相关疾病的治疗提供进一步的理论和实验依据。

英文摘要：

Bile acid efflux pump（ BSEP） is the major transporter of bile salts secreted by liver cells into the bile,the variation and inhibition of which are connected with cholestasis and druginduced liver injury. A deep understanding of the physiological and pathological function of BSEP IS achieved by analysis and summary of diseases. The paper briefly illustrates the structure,expression,regulation,substrates,inhibitors and diseases of BSEP,in order to provide further theoretical and experimental basis for the clinical treatment.