中文摘要：

核不均一性核糖核蛋白（heterogeneous nuclear ribonucleoprotein，hnRNP）家族是一组调节前体mRNA（pre—mRNA）分子的选择性剪接以及mRNA转运、翻译和稳定性等的多功能RNA结合蛋白。hnRNP Al和hnRNP A2是该家族中表达水平最高、研究最为广泛的成员，两者具有高度的序列同源型和功能相似性，在多种肿瘤组织中高表遗，通过调节多种肿瘤相关基因pre—mRNA选择性剪接和mRNA稳定性，参与调控了肿瘤细胞的增殖、凋亡、肿瘤相关的炎症与莞疫反应、上皮．．间质转换等多种细胞生物学过程，从而成为肿瘤发病分子机制以及肿瘤诊断和治疗领域研究的热点。

英文摘要：

Heterogeneous nuclear ribonucleoprotein （hnRNP） is a family of multifunctional nuclear RNA-binding proteins that regulate the alternative splicing of pre-mRNA and the transport, translation, and stability of mRNA. The most abundant and best charac- terized proteins of this group are hnRNP A 1 and hnRNP A2, which share a high degree of sequence homology and functional similarity. HnRNP A1 and hnRNP A2 are upregulated in multiple human tumors and modulate the alternative splicing and mRNA stability of vari- ous tumor-related genes critical to tumor cell growth, apoptosis, inflammatory and immune reactions, and epithelial-to-mesenchymal transition. Therefore, hnRNP A 1 and hnRNP A2 have potential diagnostic,promaostic, and therapeutic values.