中文摘要：

目的 探讨在人类多形性胶质母细胞瘤（GBM）中，变异型IκBα（IκBαM）基因对肿瘤发生发展的抑制作用及相应的作用机制。方法 将经过IκBαM基因转染的人类GBM细胞植入裸鼠皮下制作异位肿瘤生长动物模型。检测肿瘤组织的发生及发展，进一步通过免疫组织化学染色方法分析肿瘤中的微血管密度。结果 体内多形性胶质母细胞瘤的生长受到IκBαM基因的抑制，表现为不发生肿瘤或迟发，并且肿瘤生长缓慢，而且肿瘤组织中的微血管密度也显著降低。结论 IκBαM基因对人类GBM具有生长抑制作用，并且血管形成减少是其作用机制中的重要环节。

英文摘要：

Objective To investigate the role of mutant-type IκBα （IκBαM） and the mechanism in the tumorigenesis of the human glioblastoma multiform （GBM） cells. Methods IκBαM was transfected in human GBM cells, and the cells were injected subcutaneously into the nude mice. The tumors were measured and the quantification of microvessal density was analysized by immunohistochemistry. Results IκBαM could inhibit the tumor growth in vivo, representing as unable generation or tardy generation and slow growth, and the semi-quantitative analyses revealed a decrease in microvessel density in tumors. Conclusion IκBαM could significantly inhibit tumorigenecity of the human GBM cells, and the decrease of microvessel density might play an important role in this process.