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microRNA及其靶基因多态与肿瘤易感性
  • ISSN号：1007-1865
  • 期刊名称：广东化工
  • 时间：2013
  • 页码：86+88-
  • 分类：R730[医药卫生—肿瘤;医药卫生—临床医学]
  • 作者机构：[1]湖南工业大学绿色包装与生物纳米技术应用湖南省重点实验室,湖南株洲412007
  • 相关基金：国家自然科学基金重点项目（61171061）
  • 相关项目：非小细胞肺癌早期诊断分子预测模型的构建及检测芯片的研究
作者： 杨少迪|蒋佩|汤建新|
关键词： MICRORNA, 单核苷酸多态性, 疾病易感性, microRNA, single nucleotide polymorphism, disease susceptibility
中文摘要：

microRNA及其靶基因的单核苷酸多态性（SNP）影响microRNA与靶mRNA的结合和对靶基因表达的调控,使个体对多种疾病的易感性、治疗及预后存在差异.文章介绍了microRNA形成以及作用机制、microRNA及其靶基因SNP对肿瘤易感性的研究进展.

英文摘要：

Single nucleotide potymorphism （SNP） in microRNA or microRNA-binding sites can influence the risk of certain human diseases by either binding microRNA to messenger RNA （mRNA） or regulating the expression of its target genes. In this short review, we summarize the mechanism of microRNAs and describe the biogenesis of microRNAs. In addition, we discuss the potential effect of SNP within microRNA or microRNA-binding sites in the development of cancer.

同期刊论文项目
非小细胞肺癌早期诊断分子预测模型的构建及检测芯片的研究
期刊论文 41 会议论文 1
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期刊信息
  • 《广东化工》
  • 主管单位:广东省广业科技集团有限公司
  • 主办单位:广东省石油化工研究院
  • 主编：邹思民
  • 地址：广州市越秀区越华路116号
  • 邮编：510030
  • 邮箱：gdcic200@163.com
  • 电话：020-83302517
  • 国际标准刊号：ISSN：1007-1865
  • 国内统一刊号：ISSN：44-1238/TQ
  • 邮发代号:46-211
  • 获奖情况:
  • 多年来多次获原化工部及现中国化工行业协会、广东...
  • 国内外数据库收录:
  • 美国化学文摘（网络版）
  • 被引量:25903