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异补骨脂素对维生素A缺乏大鼠胚胎上颈椎发育异常的影响
  • ISSN号:1005-0205
  • 期刊名称:中国中医骨伤科杂志
  • 时间:2016.1.15
  • 页码:4-8
  • 分类:R684.7[医药卫生—骨科学;医药卫生—临床医学;医药卫生—外科学]
  • 作者机构:[1]中日友好医院,北京100029, [2]中南大学湘雅医院, [3]河南洛阳正骨医院, [4]山东文登整骨医院
  • 相关基金:国家自然科学基金(81173423)
  • 相关项目:异补骨脂素对小鼠先天性枕颈部畸形动物及细胞模型胶原及TGF信号通路影响的实验研究
中文摘要:

目的:比较手术联合补阳还五汤与单纯手术治疗督脉瘀阻型寰枢椎脱位的临床疗效。方法:自2005年1月至2014年1月,寰枢椎脱位的患者351例,分为单纯手术组及手术联合补阳还五汤治疗的手术中药组。分别比较术前、术后1个月及末次随访时,两组患者的日本骨科协会脊髓功能(JOA)评分、颈部疼痛视觉模拟评分(VAS)、颈椎功能障碍指数评分(NDI)和督脉瘀阻证候积分。结果:所有手术均顺利完成,患者随访时间6~13个月。术后两组患者督脉瘀阻证候积分、JOA评分均较术前明显提高,VAS,NDI评分均较术前明显降低,差异均有统计学意义(P〈0.05)。两组患者术前督脉瘀阻证候积分,JOA,VAS,NDI评分差异无统计学意义(P〉0.05);术后1个月时,手术中药组的督脉瘀阻证候积分和JOA评分高于手术组,VAS和NDI评分低于手术组,差异均有统计学意义(P〈0.05);至末次随访时,两组的督脉瘀阻证候积分,JOA,VAS,NDI评分虽然差异无统计学意义(P〉0.05),但手术中药组的督脉瘀阻证候积分和JOA评分高于手术组,VAS和NDI评分低于手术组,提示手术中药组疗效较单纯手术组好。结论:通过手术复位和椎管减压治疗寰枢椎脱位,可解除督脉(脊髓)的瘀阻和压迫,解剖形态结构上疏通督脉。围手术期采用中药活血化瘀、补益肝肾、益气活络,可改善微循环、消除炎症介质和保护神经细胞,进一步疏通督脉,促进恢复神经功能。

英文摘要:

Objective:To compare the clinical effect between operation combined with Buyanghuanwu decoction(BYHWD)and only operation for treating atlantoaxial dislocation of governor vessel stasis.Methods:From January 2005 to June 2015,351 cases with atlantoaxial dislocation were included.The patients were divided into the only operation group and the operation combined with BYHWD group.The Japanese orthopedic association spinal cord function(JOA)score,the visual analogue scale of neck pain(VAS),the neck dysfunction index(NDI)score and the governor vessel stasis syndrome score of the patients in two groups were compared preoperative and postoperative 1month and the last follow-up respectively.Results:All operations were completed successfully.Patients were followed up for 6to 13 months.After operation,the governor vessel stasis syndrome score and the JOA score of the patients in two groups were significantly higher than those before operation,while the VAS and NDI score were significantly lower(P〈0.05).There was no statistically significant difference in the governor vessel stasis syndrome score,JOA,VAS and NDI score between the two groups before operation(P〈0.05).The governor vessel stasis syndrome score and the JOA score in operation and combined group were higher than those of operation group,while the VAS and NDI score were lower(P〈0.05).At the last follow-up,although there was no statistical difference in the governor vessel stasis syndrome score,JOA,VAS and NDI score between the two groups(P〈0.05),the governor vessel stasis syndrome score and the JOA score in operation and combined group were higher than operation group,and the VAS and NDI score were lower,which meant the clinical effect of operation and traditional Chinese medicine group was better than the operation group.Conclusion:In the treatment of atlantoaxial dislocation,surgical reduction and spinal canal decompression can remove governor vessel(spinal cord)stasis and oppression,clear the governor pulse in an

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期刊信息
  • 《中国中医骨伤科杂志》
  • 中国科技核心期刊
  • 主管单位:中国科学技术协会
  • 主办单位:中华中医药学会 湖北省中医药研究院
  • 主编:李同生
  • 地址:武汉市珞瑜路856号
  • 邮编:430074
  • 邮箱:admin@totcm.org
  • 电话:027-87409653
  • 国际标准刊号:ISSN:1005-0205
  • 国内统一刊号:ISSN:42-1340/R
  • 邮发代号:38-182
  • 获奖情况:
  • 中国科学技术学会择优资助高科技期刊,国家自然科学基金委择优资助高科技期刊,中国科学引文数据库来源期刊,中国学术综合评价数据库来源期刊,中国期刊网、中国学术期刊期刊光盘版全文收录期刊,国际科技部中国科技论文统计源期刊
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  • 美国化学文摘(网络版),中国中国科技核心期刊
  • 被引量:15410