中文摘要：

目的：探讨环维黄杨星D（CVB-D）对麻醉犬血流动力学的影响。方法：分别以0.1、0.2、0.4 mg/kg剂量的CVB-D静脉注射给予麻醉犬,观察给药后收缩压（SAP）、平均动脉压（MAP）、心率（HR）、心输出量（CO）、冠脉流量（CBF）、每搏输出量（SV）、总外周血管阻力（TPVR）等血流动力学指标的变化。结果：CVB-D中、高剂量能降低麻醉犬HR,增加CBF,降低TPVR。此外高剂量CVB-D能升高麻醉犬SAP,增加SV,与对照组比较具有显著性差异。而CVB-D各剂量组对麻醉犬MAP和CO均未见显著影响。结论：CVB-D能够显著改善麻醉犬血流动力学及心脏自身供血,这可能是其治疗心肌缺血性疾病的基础。

英文摘要：

Objective：To investigate hemodynamic in anaesthetized dogs after the intravenous injection of cyclovirobuxine D（CVB-D）. Methods：The hemodynamic of anaesthetized dogs were observed after intravenous injection of CVB-D at doses of 0.1,0.2,0.4 mg/kg.Results：CVB-D of 0.2 and 0.4 mg/kg could decrease HR,TPVR and increase CBF.In addition,CVB-D of 0.4 mg/kg could increase SAP and SV.Yet MAP and CO of dogs showed no remarkable changes with the treatment of CVB-D.Conclusion：CVB-D has effect of improving cardiac function,which may be the mechanism of anti-myocardial ischemia effect of CVB-D.