中文摘要：

观察帕金森病（PD）模型大鼠内侧前额叶皮质（mPFC）5-羟色胺3（5-HT3）受体表达的变化，探讨其在PD非运动症状产生过程中所发挥的作用。方法：采用免疫组织化学方法，观察5-HT3受体在PD模型大鼠mPFC及其各个分区内的表达变化，并与健康对照组进行比较。结果：与对照组相比，PD大鼠损毁侧mPFC及其中央前区中部（PrCm）、前扣带回（ACd）、前边缘区（PL）、下边缘区（IL）四个分区内5-HT3受体阳性细胞明显稀疏（P〈0．05）。结论：PD状态下mPFC及其各个分区内5-HT3受体表达下调。

英文摘要：

Objectives： To investigate the altered expression of 5-HT3 receptor in medial prefrontal cortex （mPFC） of Parkinson＇s disease（PD）model rat and explore the role of 5-HT3 receptor in the pathogenesy of non-motor symptoms in PD. Methods： The altered expression of 5-HT3 receptor in mPFC and its subregions of PD rats was analysed by immunocytochemical SP technique, then it was compared to the normal rats. Results： The counting of 5- HT3 receptor positive cells in mPFC and its subregions （PrCm,ACd,PL,IL） of PD rats showed a significant decrease when compared to the normal rats, respectively （P〈0.05）. Conclusion： The result suggest that 5-HT3 receptor dysfunction in the mPFC and its subregions of PD.