中文摘要：

信号转导和转录活化因子3（signal transducers and activators of transcription3，STAT3）是参与一些细胞因子以及生长因子介导的信号转导的转录因子，在正常细胞内调控生长、增殖、分化以及凋亡等一系列生理活动．已有研究表明，JAK／STAT、MAPK、mTOR途径均可激活STAT3，持续的STAT3活化与肿瘤细胞的增殖、抗凋亡、侵袭、转移、血管形成及免疫逃逸密切相关；导致靶向抑制STAT3信号途径的寡核苷酸、小分子抑制剂、肽适配子在抗肿瘤治疗中的应用被广泛地开展．实验表明，它们具有抑制肿瘤的效果．本文重点综述了近几年STAT3在抗肿瘤进程中的功能及其在抗肿瘤治疗中的应用研究进展，并对相关问题进行讨论．

英文摘要：

Signal transducers and activators ot transcription 3 （5TA＇I＇3） , a transcmphon lactor, plays key roles in regulating the signal transduetion events mediated by cytokines and growth factors. In normal status, STAT3 was involved in many activities including survival, proliferation, differentiation and apoptosis. In addition, STAT3 was also be positively regulated by JAK/STAT, MAPK,mTOR pathway. Persistent activation of STAT3 has been demonstrated to be closely correlated to promotion of proliferation, anti-apoptosis, invasion, metastasis, angiogenesis and immune escaping behaviors in tumor cells. Therefore, strategies for inhibiting the roles of STAT3 signal pathway in tumor cells, including oligonucleotides, small molecular weight inhibitors and peptide aptamers, have been extensively studied. Current results showed that these strategies could inhibit tumor process and should be promising in anti- tumor therapy. In this study, functions of STAT3 and its potential app｜ieations in anti-tumor therapy would be reviewed.