中文摘要：

miRNA是一类非编码的小RNA分子,可以导致其靶基因降解或阻碍其靶基因翻译。miRNA占人体基因总数的2%-3%,调控人类基因组中30%以上的基因。它的表达异常引起相应调控网络紊乱是疾病发生的重要原因。治病求本是中医学的一个特有概念。它指的是从根本病因上去治疗,以恢复人体阴阳平衡状态,从而从根源上消除疾病。治病求本是中医的优势和特色所在。文章采用病证结合、方证对应的临床研究模式,探讨以miRNA及其调控网络为切入点研究中医治病求本机制的思路。

英文摘要：

MiRNA（microRNA） are small non-coding RNAs.They result in translational repression or target degradation of target genes.MiRNA is about 2%-3% of the whole human genome and regulate more than 30% human genes.Their abnormal expressions will cause the disorders of its regulating networks that is an important cause of diseases.The ＂causal treatment＂ is a unique concept of traditional Chinese medicine.It means that treatment should be based on the essential pathogen of diseases to regain the ying-yang balance of human body.Diseases could be eliminated from their roots.It is one of the advantages and characteristics of TCM.Baesd on the clinical research model of combination of disease and syndrome and formula related to syndrome,we explored the research framework of the mechanism of the ＂causal treatment＂ of TCM from miRNA and their regulating networks.