中文摘要：

目的：检测烟雾病患者血清血管生成因子和炎性细胞因子水平，探讨其在烟雾病发病中的作用。方法利用流式细胞术微球阵列法检测56例烟雾病和26名健康对照者血清血管内皮生长因子（vascular endothelial grow th factor, VEGF ）、血管生成素－1（angiopoietin－1, Ang－1）、白细胞介素－8（interleukin－8, IL－8）、粒细胞集落刺激因子（granulocyte colony stimulating factor, G －CSF）、粒细胞－巨噬细胞集落刺激因子（granulocyte－macrophage colony stimulating factor, GM －CSF）和单核细胞趋化蛋白－1（ monocyte chemotactic protein 1, MCP－1）水平。结果烟雾病组血清 VEGF [（2.81±1.77）pg/ml 对（1.98±0.66）pg/ml； t =3.081， P =0.003]和 IL－8[（0.89±0.69）pg/ml 对（0.63±0.45）pg/ml；t＇=2.0371，P 〈0.05]水平显著高于健康对照，而 Ang－1水平显著低于健康对照组[（830.01±289.29）pg/ml 对（961.65±232.87）pg/ml；t =－2.032，P =0.045]。结论烟雾病患者血清 VEGF、Ang－1和 IL－8水平与健康对照者存在显著差异，提示血管生成因子和炎性细胞因子可能在烟雾病发病中起着一定的作用。

英文摘要：

Objective To detect the serum levels of angiogenic factors and inflammatory cytokines in patients w ith moyamoya disease and explore their roles in the pathogenesis of the disease. Methods The serum levels of vascular endothelial grow th factor （VEGF）, angiopoietin -1 （Ang-1）, interleukin-8 （IL-8）, granulocyte colony stimulating factor （G -CSF）, granulocyte-macrophage colony stimulating factor （ GM-CSF） and monocyte chemotactic protein 1 （MCP -1） in 56 patients w ith moyamoya disease and 26 healthy controls w ere measured by cytometric bead array. Results The serum levels of VEGF （2.81 ± 1.77 pg/ml vs.1.98 ±0.66 pg/ml; t = 3.081, P = 0.003 ） and IL-8 （0.89 ±0.69 pg/ml vs.0.63 ± 0.45 pg/ml; t＇=2.0371, P 〈 0.05） in the moyamoya disease group w ere significantly higher than those in the healthy control group, and the serum level of Ang -1 in the moyamoya disease group w as significantly low er than that in the healthy control group （830.01 ±289.29 pg/ml vs.961.65 ±232.87 pg/ml; t =-2.032, P =0.045）. Conclusions There are significant difference in serum levels of VEGF, Ang -1 and IL-8 betw een patients w ith moyamoya disease and healthy controls. The results indicate that angiogenic factors and inflammatory cytokines play some roles in the pathogenesis of moyamoya disease.