中文摘要：

采用寇氏改良法研究了咪唑型离子液体对小鼠的急性毒性,并考察了烷基侧链长度对其毒性的影响,同时采用HE染色法观察了其对小鼠肝脏的毒性.结果表明,4种咪唑型离子液体（[C10mim]Br、[C12mim]Br、[C14mim]Br和[C18mim]Br）对小鼠肝脏均有损伤,其LD50值在98.91～220.16mg·kg^-1之间,为中等毒性.咪唑型离子液体对小鼠的急性毒性与其侧链长度有关,当碳链长度为14时,其毒性最强.

英文摘要：

The acute toxicity to mice of imidazolium ionic liquids （ILs） with varying alkyl chain lengths was evaluated by Karber＇s modified method and hepatic lesions were observed by hematoxylin-eosin staining. The results showed that four types of ILs including [C10mim]Br,[C12mim]Br,[C14mim]Br and [C18mim]Br produced obvious hepatic lesions in mice,and the LD50 of the ILs ranged from 98.91 to 220.16 mg·kg^-1,indicating a medium toxicity. The acute toxicity of different ILs to mice was related to the length of its side chain,and the strongest toxicity was observed for the ILs with the alkyl chain length of fourteen.