中文摘要：

目的：采用磁共振动脉自旋标记技术（ASL）对快速动眼睡眠障碍（R BD）患者的脑血流灌注异常情况进行研究,探讨ASL的应用价值。方法：我们的研究包括经同步视频多导睡眠监测（PSG）证实的原发性RBD患者20例及年龄、性别与RBD患者匹配的健康志愿者15例。所有的被试均在GE Discovery MR750磁共振扫描仪上进行ASL序列和3D-BRAVO序列的扫描。ASL的数据分析采用基于体素的方法在SPM8软件上进行。RBD组和对照组被试脑皮质灌注的差异采用双样本t检验进行分析。结果：RBD患者皮质灌注增高的区域主要位于额叶、前扣带皮质、辅助运动区、壳核、海马旁回、楔前叶和脑桥等;皮质灌注降低的区域主要位于枕叶、舌叶、颞叶中部等。结论：ASL技术可以发现RBD患者的灌注异常,在神经退行性病变的研究方便有较大的应用价值。

英文摘要：

Purpose：To analyze the differences between RBD（REM Sleep Behavior Disorder） group and control group in cortical perfusion by MRI arterial spin labeling（ASL） technique.Methods：Twenty patients with idiopathic RBD confirmed by polysomnography and 15 healthy volunteers were enrolled in our study.They were undergone MRI scanning,which included ASL and 3D-BRAV0 sequences,on a GE Discovery MR750 machine.The ASL data were analyzed by SPM8 software.And two samples t-test was used to analyze the difference of the cortical perfusion between RBD group and control group.Results：Compared with control group,cortical perfusion in RBD patients with increased regional cerebral blood flow areas were mainly located in the frontal lobe,the anterior cingulate cortex,supplementary motor area,putamen,parahippocampal gyrus,precuneus and pons,etc.;and decreased cortical perfusion areas were mainly located in the occipital lobe,lingula lobe,middle temporal lobe and so on.Conclusion：Abnormal cortical perfusion in RBD patients can be revealed by MRI ASL technique,and ASL technique has great value in study of neurodegenerative diseases of the brain.