AIM: To compare differences between volumetricinterpolated breath-hold examination (VIBE) usingtwo-point Dixon fat-water separation (Dixon-VIBE)and chemically selective fat saturation (FS-VIBE) withmagnetic resonance imaging examination.METHODS: Forty-nine patients were included, whowere scanned with two VIBE sequences (Dixon-VIBEand FS-VIBE) in hepatobiliary phase after gadoxeticacid administration. Subjective evaluations includingsharpness of tumor, sharpness of vessels, strength andhomogeneity of fat suppression, and artifacts that werescored using a 4-point scale. The liver-to-lesion contrastwas also calculated and compared.RESULTS: Dixon-VIBE with water reconstruction hadsignificantly higher subjective scores than FS-VIBE instrength and homogeneity of fat suppression (〈 0.0001)but lower scores in sharpness of tumor (P 〈 0.0001),sharpness of vessels (P = 0.0001), and artifacts (P= 0.034). The liver-to-lesion contrast on Dixon-VIBEimages was significantly lower than that on FS-VIBE(16.6% ± 9.4% vs 23.9% ± 12.1%, P = 0.0001).CONCLUSION: Dixon-VIBE provides stronger andmore homogenous fat suppression than FS-VIBE, whilehas lower clarity of focal liver lesions in hepatobiliaryphase after gadoxetic acid administration.Key words: Dixon-volumetric interpolated breath-holdexamination; Fat saturation-volumetric interpolatedbreath-hold examination; Gadoxetic acid; Volumetricinterpolated breath-hold examination; Magnetic