中文摘要：

目的探讨缺血性脑白质脱髓鞘病变的影响因素。方法选取我院2015年1月—2015年6月收治的缺血性脑白质脱髓鞘病变64例作为研究对象,按照病情严重程度分为轻中度组和重度组,每组各32例,分析缺血性脑白质脱髓鞘病变的高危因素。结果两组年龄、血同型半胱氨酸（Hcy）水平、2型糖尿病、高血压病、颈动脉硬化比较差异均有统计学意义（P〈0.05）。logistic回归分析显示,年龄、血Hcy水平、2型糖尿病、高血压病与缺血性脑白质脱髓鞘病变有一定相关性。结论年龄、血Hcy水平、2型糖尿病、高血压病与缺血性脑白质脱髓鞘病变密切相关,早期诊断并积极干预,可减轻脑组织及神经系统损害。

英文摘要：

Objective To investigate influencing factors in patients with ischemic brain white matter demyelinating lesions. Methods A total of 64 patients with ischemic brain white matter demyelinating lesions admitted from January to June 2015 were divided into mild-moderate group（ n = 32） and severe group（ n = 32） according to the severity. High risk factors of ischemic brain white matter demyelinating lesions were analyzed. Results There were significant differences in age,blood homocysteine（ Hcy） level,type 2 diabetes mellitus and hypertension and carotid atherosclerosis between the two groups（ P〈0. 05）. Logistic regression analysis showed that the age,blood Hcy levels,type 2 diabetes mellitus,and hypertension were related to ischemic brain white matter demyelinating lesions. Conclusion The age,blood Hcy level,type 2 diabetes mellitus and hypertension are closely related to ischemic brain white matter demyelinating lesions. Early diagnosis and active intervention can decrease damage of brain tissue and nervous system.