中文摘要：

目的探讨行降纤疗法后缺血性卒中患者出血转化的影响因素。方法收集2011年3月至2016年2月行降纤治疗的102例缺血性卒中患者为研究对象。根据影像学的结果将所选患者分为出血组（n=28）与非出血组（n=74）,然后运用统计学分析方法对可能影响缺血性卒中患者行降纤疗法后的出血转化的危险因素进行统计学分析。结果行降纤疗法后缺血性卒中患者发生出血转化的发生率为27.45%;心源性脑卒中与美国国立卫生研究院卒中量表（NIHSS）评分高均是行降纤疗法后缺血性卒中患者发生出血转化的独立危险因素（OR=1.041、0.319,P=0.032、0.028）。结论对NIHSS评分高及心源性脑卒中的缺血性卒中患者进行降纤治疗时要警惕出现出血转化的风险。

英文摘要：

Objective To explore the influence factors on hemorrhagic transformation after defibrase therapy of the patients with ischemic stroke.Methods A total of 102 patients with ischemic stroke were collected after defibrase therapy from March 2011 to February 2016 in hospital.All the patients were divided into bleeding group（n=28）and non-bleeding group（n=74）by the imaging results.And then the risk factors for bleeding on hemorrhage of the patients with ischemic stroke after defibrase therapy were analyzed by the statistical analysis.Results The incidence of hemorrhagic transformation of the patients with ischemic stroke after defibrase therapy was 27.45%.The cardiac cerebral apoplexy and the higher NIHSS score were the independent risk factors to the patients with ischemic stroke after defibrase therapy（OR=1.041 and 0.319,P=0.032 and 0.028）.Conclusion Patients with ischemic stroke after defibrase therapy who has cardiac cerebral apoplexy and higher NIHSS score should be aware of having the risk of hemorrhagic transformation.