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小白杏杏仁油免疫调节及对S180肉瘤抑制作用研究
  • ISSN号:1003-0174
  • 期刊名称:中国粮油学报
  • 时间:0
  • 页码:-
  • 分类:R151.1[医药卫生—营养与食品卫生学;医药卫生—公共卫生与预防医学]
  • 作者机构:[1]食品科学与技术国家重点实验室江南大学食品学院,无锡214122, [2]石河子大学食品学院,石河子832000
  • 相关基金:国家自然科学基金(31000766)
  • 相关项目:新疆小白杏杏仁油中生物活性物质指纹图谱构建及其免疫调节和抗肿瘤作用机理研究
中文摘要:

研究新疆小白杏杏仁油对大鼠免疫调节作用及对S180肉瘤抑制作用。采用环磷酰胺诱导腹腔注射的方法建立免疫力低下大鼠模型,设立喂养对照组及体外细胞培养阴性对照组,通过酶联免疫吸附检测及细胞培养观察研究其免疫调节及对S180肉瘤抑制作用。新疆小白杏杏仁油可显著提高免疫力低下大鼠模型的脾脏指数(P〈0.01)、胸腺指数(P〈0.01)及肝脏指数(P〈0.05);对大鼠血清中IgA、IgM、IgG及IL-12指标的改善程度达到较显著差异水平(P〈0.01),IL-2和TNF-α指标的改善程度呈现显著差异水平(P〈0.05),并对体外培养的S180肉瘤细胞具有明显地抑制作用。

英文摘要:

To investigate the immunoregulatory activities and the inhibition effect on S180 sarcom of xiao - bai apricot almond oil. The rat model of immunosuppression was established by intraperitoneal injection of cyclophospha- mide, and the feeding control groups, including empty control group, model control group and sample test group, and cell vitro -culture groups were set up in this paper. The immunoregulatory activities and the inhibition effect on S180 sarcom of xiao -bai apricot almond oil were studied respectively by enzyme -linked immunosorbent assay and cul- tured cell observation. Xiao - bai apricot almond oil could increase the spleen index ( P 〈 0.01 ) , the thymus index (P 〈 0. 01 ) and the liver index ( P 〈 0.05 ) ; the expression levels of serum immunoglobulin and immune factors, such as IgA ,IgM ,IgG and IL -12 were improved greatly (P 〈0.01 ) , the expression levels of other immune factors, such as IL - 2 and TNF - α, were improved obviously( P 〈 0.05 ), and the growth rate of S180 sarcom was inhibited noticeably by the apricot almond oil sample.

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期刊信息
  • 《中国粮油学报》
  • 中国科技核心期刊
  • 主管单位:中国科学技术协会
  • 主办单位:中国粮油学会
  • 主编:于衍霞
  • 地址:北京市西城区百万庄大街11号
  • 邮编:100037
  • 邮箱:lyxbao@126.com
  • 电话:010-68357510
  • 国际标准刊号:ISSN:1003-0174
  • 国内统一刊号:ISSN:11-2864/TS
  • 邮发代号:80-720
  • 获奖情况:
  • 国内外数据库收录:
  • 被引量:22098