中文摘要：

目的研究岩白菜素在大鼠肠道中的吸收机理。方法采用HPLC测定大鼠在体肠实验中岩白菜素的含量，从吸收部位、药物浓度、pH三方面研究岩白菜素在大鼠小肠中的吸收特性。结果岩白菜素在全肠段均有吸收，但不同肠段的吸收存在差异。药物浓度和循环液的pH对吸收均有影响。结论岩白菜素在大鼠肠道内吸收较少，吸收机制可能为被动扩散。

英文摘要：

OBJECTIVE To investigate the absorption characteristics and mechanism of bergenin in rat intestine. METHODS The concentration of bergenin was determined by HPLC, and the absorption mechanism was determined using in situ perfusion. The effects of pH value, absorption site and drug concentration on bergenin absorption were investigated. RESULTS Bergenin showed absorption behaviour in the whole intestine, but the amounts were different at duodenum, jejunum, ileum and colon. The concentration and the pH of drug solution had effect on the absorption kinetics. CONCLUSION Bergenin was absorbed badly at all segments of intestine in rats. The absorption of the drug conforms to the passive transport mechanism.