中文摘要：

目的 研究以低压氧方法建立的阻塞性睡眠呼吸暂停综合征（OS／kS）模型小型猪的睡眠生理。方法 12只成年雄性小型猪随机分为模型组（A）、对照组（B）。A组置于双室低压氧舱一室，仓内压力约53．9kPa，氧浓度10％-11．2％；B组置于低压仓二室，舱内压力为海平面气压，氧浓度21％。两组每天均入仓6h，连续22天。第23天，小型猪行睡眠监测，记录其胸、腹部运动，呼吸气流，心率，血氧饱和度（SpO2）5项指标，软件分析数据得出呼吸暂停低通气指数（AHI）、低通气指数（HI）、平均Spoz。之后处死小型猪，取其咽部组织行病理检查。结果A组与B组比较AHI（16．1±8.3 vs 2．3±1．6）、HI（4．3±3.1 vs 1．3±1．0）、SpQ（86．7±3．6 vs 94．5±1．8）均有显著差异（P〈0．05）。A组上皮组织增生伴角化，黏膜下层水肿、纤维组织增生，肌肉萎缩、横纹不清，肌间脂肪增生。B组咽部黏膜为复层扁平上皮，黏膜下层薄，肌层横纹清，肌间脂肪少。结论 低压氧方法建立的OSAS模型小型猪睡眠生理变化规律与人OSAS患者类似。

英文摘要：

Objective To study the physiology of sleeping in a swine model with obstructive sleep apnea syndrome （OSAS） reproduced by high altitude and hypoxia. Methods Twelve male minipigs were randomly assigned to 2 groups, named A and B. The pigs of Group A were placed in Room 1, which was a double-room altitude chamber, and the pressure in it was adjusted to 53. 9 kPa with an oxygen con- centration of 10. 0%-11.2%. The pigs of Group B were kept in Room 2 with altitude of sea level and oxygen concentration of 21%. All the anima/s were kept in their respective rooms for 6 hours per day and for 22 consecutive days. On the 23rd day sleeping was monitored, at the same time the movements of chest and abdomen, respiratory airflow, heart rate, and pulse oxygen saturation （SpOz） were recorded. Apnea/Hypopnea Index （AHI）, Hypopnea Index （HI）, and average SpO2 were derived from analysis of the data of sleeping monitoring. Pigs were sacrificed after the experiment, and pharyngeal tissue was harvested for pathological examination. Results The AHI （16. 1±8. 3 vs 2.3v1.6）, HI （4.3±3.1 vs 1.3±1.0）, SpO2（86. 7±3. 6 vs 94.5±1.8） of pigs of group A showed were have significant differences compared with that of the control （P〈0. 05）. Pathological examination： Group A： The pharyngeal epithelium was cornified and proliferated, with submucosal edema and proliferation of connective tissue. The muscular layer was thickened with indistinct transverse striation. Local infiltration of fat cells could be observed among muscular fibers. Group B： The mucosa of pharynx was co~,,ered by stratified squamous epithelium. Submucosa was thin. Striation was clear in the muscular layer with less fat cells among muscular fibers. Conclusion The physiology and the pathology of pharyngeal tissue of minipig of hypoxia showed similar changes in patients with OSAS.