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帕金森病早期生物学标记物研究新进展
  • ISSN号：1672-6731
  • 期刊名称：《中国现代神经疾病杂志》
  • 分类：R742.5[医药卫生—神经病学与精神病学;医药卫生—临床医学] R992[医药卫生—毒理学;医药卫生—药学]
  • 作者机构：[1]上海交通大学医学院附属瑞金医院神经科,上海交通大学医学院神经病学研究所,200025
  • 相关基金：国家自然科学基金资助项目（项目编号：30730096）;国家高技术研究发展计划（863计划）专题课题（项目编号：2007AA02Z460）
作者： 乐卫东[1], 杜芸兰[1]
关键词： 帕金森病, 生物学标志, 综述文献
中文摘要：

帕金森病（PD）是中老年人常见的中枢神经系统变性疾病，≥65岁人群患病率约为1％。以黑质多巴胺能神经元变性缺失和残存神经元出现特征性包涵体——路易小体（LB）为主要病理改变。临床表现为静止性震颤、肌强直、动作迟缓和姿势平衡障碍。帕金森病起病隐匿，早期黑质多巴胺能神经元逐渐缺失，无明显临床症状，这一病理过程可持续4～6年。

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帕金森病早期诊断生物学标记及基因靶向治疗研究
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期刊信息
  • 《中国现代神经疾病杂志》
  • 中国科技核心期刊
  • 主管单位:中华人民共和国卫生部
  • 主办单位:中国医师协会 天津市科学技术协会 天津市神经科学学会
  • 主编：只达石
  • 地址：天津市津南区吉兆路6号
  • 邮编：300350
  • 邮箱：xdsjjbzz@263.net.cn
  • 电话：022-59065611/12
  • 国际标准刊号：ISSN：1672-6731
  • 国内统一刊号：ISSN：12-1363/R
  • 邮发代号:6-182
  • 获奖情况:
  • 国内外数据库收录:
  • 被引量:6201