中文摘要：

目的：研究甘肃兰州地区人乳头瘤病毒16亚型感染后诱发宫颈癌的发病机制。方法：人乳头瘤病毒16亚型感染经病理确诊的宫颈鳞癌4例,活检取子宫颈癌组织及自身正常宫颈组织标本,用含20 600条人类全基因的OligoDNA基因芯片微阵列比较基因组杂交技术筛选出差异表达的基因进行分析。结果：4例宫颈癌组织中共同差异表达的基因有302条。121条上调,181条下调。结论：多因素、多基因共同作用导致HPV16亚型引发宫颈癌。

英文摘要：

Objective： To study the molecular pathogenesis of cervical cancer infected with human papillomavirus （HPV） type 16 in Lanzhou area of Gansu province. Methods： Four patients infected by HPV type 16 were diagnosed as cervical cancer by pathology. The cervical cancer tissues and normal cervix tissues were biopsied for screening of human gene expressions by microarray--based comparative genomic hybridization with 20 600 human genes of cDNA microarrays. Results： A total of 302 differentially expressed genes were identified in the 4 cervical cancer samples, including 121 up - regulated and 181 down - regulated genes. Conclusion：Cervical cancer induced by HPV type 16 may result from polygene and multiple factors.