中文摘要：

目的 探讨导航经颅磁刺激和功能磁共振成像在汉语语言功能皮质定位中的作用,在组水平和个体水平描绘关键语言功能区和参与语言功能区的分布.方法 选用不出声的图片命名任务对20名健康志愿者进行功能磁共振脑功能成像,获得脑激活图后确定全部参与语言功能区.选取图片命名任务,在神经导航系统的引导下给予同步的重复经颅磁刺激,确定受试者的关键语言功能区,并进一步在组水平和个体水平上分析关键语言功能区和参与语言功能区的特点.结果 在个体水平上,汉语语言功能区分布有较大的差异;在组水平上,参与语言功能区较关键语言功能区激活范围广泛,但语言功能区的总体分布趋势一致,即左侧优势半球的腹侧中央前回、经典Broca区以及右侧非优势半球的额下回后部.结论 联合应用导航经颅磁刺激技术和功能磁共振成像能够定位关键语言功能区和参与语言功能区,既可在组水平上分析语言功能的分布趋势,亦可在个体水平上精确规划出语言功能区,有助于指导语言功能区的手术治疗.

英文摘要：

Objectives To investigate the effects of the navigated transcranial magnetic stimulation and functional magnetic resonance imaging in the cortical localization of Chinese language function and to describe the distributions of the essential language functional areas and participating language functional areas at group level and individual level.Methods Twenty healthy volunteers underwent functional magnetic resonance imaging of brain function by selecting the covert pictures to name task.All participating language functional areas were identified after obtaining the brain activation maps.The picture naming tasks were selected.Under the navigation of the neuronavigation system,the synchronous repetitive transcranial magnetic stimulation was conducted.The essential language functional areas of the participants were identified,and the characteristics of the essential language functional areas and participating language functional areas were analyzed on the group level and individual level.Results At the individual level,there was greater difference in the distribution of Chinese language functional areas;at the group level,the range of activation was wider in the participating language functional areas than the essential language functional areas,but the overall distribution trend of the language functional areas was united,including the ventral precentral gyrus of the left dominant hemisphere,classic Broca＇s area,and pars opercularis of the right non-dominant hemisphere.Conclusions The combined application of transcranial magnetic stimulation and functional magnetic resonance imaging is able to locate the essential language functional areas and participating language functional areas,it can either analyze the language function distribution trend at the group level or precisely plan the language functional areas at the individual level.It contributes to guide surgical treatment of language functional areas.