中文摘要：

目的：探讨苦碟子注射液对急性腔隙性脑梗死患者脑血管反应性（CVR）的影响。方法：选择急性腔隙性脑梗死患者80例,采用随机、双盲和平行对照的方法,把患者分为对照组和治疗组,每组各40例。两组患者均接受脑梗死的基本治疗,对照组患者给予胞磷胆碱1 g/d治疗;治疗组患者给予苦碟子注射液40 ml/d加胞磷胆碱1 g/d治疗,两组患者均共治疗14 d。治疗前后,采用经颅多普勒（TCD）结合屏气试验检测两组患者的屏气指数（BMI）;观察苦碟子注射液对急性腔隙性脑梗死患者脑血管反H应性的影响。结果：治疗前,两组患者的屏气指数无差别（P〉0.05）;治疗后,治疗组患者的屏气指数比治疗前明显提高（P〈0.05）,较对照组亦增加（P〈0.05）。结论：苦碟子注射液具有改善急性腔隙性脑梗死患者脑血流动力学的作用,是治疗急性腔隙性脑梗死患者的有效药物。

英文摘要：

Objective To study effect of Kudiezi injection on cerebral vasomotor reactivity in patients with acute cerebral lacu-nar infarction. Methods： A randomized,d o u b le -b l in d,parallel-controlled trial was employed. Eighty patients with acute cerebral la-cunar infarction were divided into control group and treatment group, 40 cases in each group. They all accepted the basic treatment of cerebral infarction. Besides,the control group was treated with Citicoline injection （1g/d ,i. v d r i p ） ,while the treatment group was treated with Kudiezi injection （40mL/d,i. v d r ip ） . After 14 days treatment,transcranial Doppler and breath holding test were used to evaluate the cerebral vasomotor reactivity by testing breath-holding index before and after the intervention,and the effects of Kudiezi injection on cerebral vasomotor reactivity were obser^^ed. Results： The levels of the brea th -h olding index of the two groups had no sta-tistical significant difference before the treatment （ P〉0.05）. The level of the breath-holding index of treatment group increased signif-icantly after Kudiezi treatment （P〈0.05）,and was higher than that of control group （P〈0. 05）. Conclusions： Kudiezi can improve the cerebrovascular hemodynamics of acute cerebral lacunar infarction patients, and is an effective drug for the treatment of acute cere-bral lacunar infarction.