中文摘要：

目的观察神经节苷脂（Gg）注射液对重症颅脑损伤患者血清神经元特异性烯醇化酶（NSE）及S100B蛋白浓度的影响。方法 68例急性颅脑损伤患者随机分为对照组34例和试验组34例。对照组给予复方甘露醇注射液,每次200m L,每天2次,静脉滴注;脑复康1.2 g,每天3次,口服;试验组在对照组的基础上静脉滴注单唾液酸四己糖神经节苷脂100 mg,每天1次,2组疗程均为2个月。分别在患者住院后的第8,24,48,72,120 h采集空腹外周静脉血,用酶联免疫吸附法对2组患者血清NES和S100B蛋白进行检测,同时评价2组患者的临床疗效,观察2组的药物不良反应发生情况。结果治疗后120 h,试验组和对照组的血清NSE分别为（13.21±2.78）,（18.52±3.45）ng·mL^-1,S100B分别为（2.08±0.85）,（3.76±2.14）ng·mL^-1,差异有统计学意义（P〈0.05）。试验组有效率为82.35%（28/34例）,对照组为58.82%（20/34例）,差异有统计学意义（P〈0.05）。治疗后2,4周,试验组的简易精神状态检查量表（MMSE）评分分别为（23.44±3.15）,（27.41±3.48）分,对照组的MMSE分别为（20.35±2.35）,（22.24±2.97）分,差异有统计学意义（P〈0.01）。2组治疗过程中均没有出现明显的药物不良反应。结论神经节苷脂注射液可以有效降低重症颅脑损伤患者的血清NSE和S100B蛋白浓度。

英文摘要：

Objective To investigate the correlation between ganglioside（ Gg） injection and serum neuron- specific enolase（ NSE） and S100 B protein concentration in patients with severe craniocerebral injury.Methods Sixty- eight patients with acute craniocerebral injury were randomly divided into control group（ n = 34） and treatment group（ n = 34）. Patients in control group were intravenously infused mannitol injection 200 m L,twice a day and orally given norepinephrine 1. 2 g,3times a day. Patients in treatment group were given intravenous infusion of monosialoglycoside ganglion glucoside 100 mg, once a day. All patients were treated for 2 months. Serum NES and S100 B protein levels were measured by enzyme- linked immunosorbent assay in two groups in24,48,72,and 120 h after hospitalization. And the adverse drug reactions in two groups were observed. Results After 120 h treatment,the serum NSE levels in treatment group and control groupwere（ 13. 21 ± 2. 78）,（ 18. 52 ± 3. 45） ng ·mL^-1 The S100 in treatment group and control group were（ 2. 08 ± 0. 85）,（ 3. 76 ± 2. 14） ng·mL^-1 P〈0. 05）. The effective rate was 82. 35%（ 28 /34 cases） in treatment group,had significant difference with that in control group,which was 58. 82%（ 20 /34 cases,P〈0. 05）. The MMSE scores in treatment group after 2,4 weeks were 23. 44 ± 3. 15,27. 41 ± 3. 48,had significant difference with those in control group,which were 20. 35 ± 2. 35,22. 24 ± 2. 97（ P〈0. 01）. There were no adverse drug reactions in two groups during the treatment. Conclusion Gg injection can effectively reduce the levels of serum NSE and S100 B protein in patients with severe traumatic brain injury.