中文摘要：

p53的凋亡刺激蛋白（ASPP）基因家族可以调控p53，在肿瘤的发生、发展中起重要作用。肾癌是泌尿系统常见的恶性肿瘤之一，其发病较为隐匿，缺乏早期临床表现。肾癌最主要的治疗方法是根治性肾切除术，其具有多药物耐药基因，对放射治疗及化学治疗不敏感。目前，ASPP基因在肾癌中的研究非常匮乏，但ASPP2在肾癌中的作用已有研究证明，且其家族在肿瘤中的作用明确。近年来，肾癌的基因靶向治疗已逐渐成为肾癌治疗的新热点，为肾癌的早期诊断和治疗提供了新思路。

英文摘要：

The apoptosis stimulating proteins of p53 （ASPP）gene family bind to p53 which are key players in controlling apoptosis and cell growth. Renal carcinoma is a common malignant tumor in urinary system, and its onset is very insidious, and lack of early clinical manifestations. The main treatment is radical nephrectomy. Renal carcinoma has multi-drug resistance gene and is not sensitive to radiotherapy and chemo- therapy. Now, the study of ASPP gene in renal carcinoma is very scarce, but the role of ASPP2 in renal cell carcinoma has been demonstrated, and the role of the gene family in the tumor is clear. In recent years, the gene target therapy of renal carcinoma has gradually become a new direction for the treatment, which provides new ideas for the early diagnosis and treatment as well.