中文摘要：

纤维化是指由于多种因素损伤器官实质细胞，使其发生坏死，组织内细胞外基质（ECM）异常增多和过度沉积的病理过程。TGF-β1超家族蛋白是目前已知最重要的致纤维化的细胞因子。骨形态发生蛋白（BMPs）能控制细胞增生与分化，BMPs／Smads信号通路能够在多个环节拈抗TGF-β1的致纤维化作用，尤其是其中的骨形态发生蛋白7（BMP7）具有显著的抗纤维化作用。

英文摘要：

Fibrosis is caused by many factors. These factors cause too much ECM deposit in tela. The TGF-β1 is known as yet to be the most important cytokine to cause fibrosis. BMPs/Smads signaling can rivalry the fibrogenatie activity of TGF-β1. BMP7 has been shown to have anti-fibrosis effect in different renal diseases models, in cultured mesangial cells, lens epithelial cells, mammary ductal epithelial cells, in lung fibrosis and in peritrabeeular fibrosis. BMP-7 may be an effective treatment to fibrosis in the future.