中文摘要：

神经珠蛋白（neuroglobin，Ngb）是一种特异性表达于脑组织的携氧球蛋白，参与能量代尉、线粒体功能以及细胞存活和增殖的信号通路调节。在生理条件下，Ngb以亚铁脱氧六配体形式存在，具有较强的氧亲和能力。缺血缺氧时，脑组织内的Ngb表达上调，并通过与其下游的多种蛋白相互作用，对损伤脑组织起着保护作用。

英文摘要：

Neuroglobin （Ngb） is an oxygen-carrying globin that specifically expresses in brain tissue. It is involved in energy metabolism, mitochondrial function, as well as cell survival and proliferation of signaling pathway regulation. Under physiological conditions, Ngb presents as a form of ferrous deoxy hexacoordination, which has stronger oxygen affinity. During ischemia and hypoxia, the expression of Ngb is upregulated in brain tissue and interacts through a variety of proteins of its downstream, and plays a protective role for the damaged brain tissue.