中文摘要：

谷氨酸转运体-1（glutamate transporter-1,GLT-1）是脑组织内的一种重要谷氨酸转运体,可将胞外谷氨酸转运至星形胶质细胞内.在谷氨酰胺合成酶的作用下,谷氨酸转化为可被神经元利用的谷氨酰胺.脑缺血时,细胞外谷氨酸浓度急剧升高,从而对神经元产生兴奋性毒性作用.头孢曲松、亚致死性缺血、低压低氧等预处理均可通过调节GLT-1的表达和改善其功能而起神经保护作用.

英文摘要：

Glutamate is an essential excitatory neurotransmitter which regulates brain functions.An increase in extracellular glutamate could excessively activate ionotropic glutamate receptors,initiate calcium overload,and lead to cell death after cerebral ischemia.Glutamate transporter-1 （GLT-1） is one of the major glutamate transporters expressed predominantly in astrocytes.Astrocytes also express the enzyme glutamine synthetase （GS） which converts the glutamate to glutamine; the latter is then ＆#39;recycled＆#39; into neurons.Pretreatment with ceftriaxone （CEF）,ischemia and intermittent hypobaric hypoxia could lead to neuroprotection by increasing the expression of GLT-1 and regulating the activity of glutamate transporter in brain.