中文摘要：

成纤维母细胞是乳腺癌间质的重要组成成分之一,该细胞与正常乳腺组织间质的成纤维细胞在生物学特性上存在明显的差异,不仅在肿瘤的发生、发展中起重要作用,而且与患者的预后密切相关。近年来,研究还显示乳腺癌相关成纤维母细胞与治疗效果有关,将成为乳腺癌治疗策略中不可忽略的一个方面。

英文摘要：

Carcinoma-associated fibroblasts（CAFs） is an vital part of the stroma in breast cancer.There is a big differences in the biological features between the normal mammary fibroblasts and carcinoma-associated fibroblasts.CAFs plays a critical role in tumor initiation,growth,metastasis and prognosis as well.Recently,researches suggest that CAFs contribute to efficacy of antitumor therapy and targeting CAFs may become a viable approach for tumor treatment.