作为新型高尔基蛋白,GOLPH2的表达与维持高尔基体结构的完整性相关。作为癌蛋白,GOLPH2的表达与肿瘤细胞恶性生物学行为相关。GOLPH2在肿瘤发生和转移中的重要作用使之成为肿瘤诊断和治疗的新靶点。
As a novel Golgi protein, GOLPH2 expression is associated with maintaining the structural integrity of the Golgi apparatus. As an oncoprotein, GOLPH2 expression is associated with malignant biological behavior of cancer cells. Important roles of GOLPH2 in the tumorigenesis and metastasis make it become a new target for tumor diagnosis and treatment.