中文摘要：

目的：研究氯霉素前体D-（-）苏式-对硝基苯基-2氨基-1，3-丙二醇（D-（-）-NAD）分子印迹聚合物的制备及识别特性。方法：以D-（-）-NAD为模板分子，甲基丙烯酸（MAA）为功能单体制备分子印迹聚合物，采用^1HNMR和紫外光谱研究其形成机制，用平衡结合实验考察其识别特性及印迹效率。结果：在乙醇溶剂中，模板可通过硝基、氨基与MAA发生氢键或离子作用，该条件下制备的分子印迹聚合物对模板分子具有明显的专一识别能力及立体选择性。结论：该印迹聚合物可进一步用作D-（-）-NAD的高效吸附剂或手性色谱分离固定相。

英文摘要：

OBJECTIVE ： To study the preparation method and the recognition properties of D - （ - ） - Threo - para - nitrophenyl - 2- amino- 1, 3- propanediol（D- （ - ） - NAD） - precursor of chloramphenicol imprinted polymers. METHODS： The molecularly imprinted polymers were prepared with D （ - ） - NAD as template molecules and with methylacrylic acid （MAA） as functional monomer. The formative mechanism of the imprinted polymers was evaluated by ^1H NMR and ul- traviolet- visible （UV） spectra. The binding characteristic and imprinting efficiency of polymers were investigated by using equilibrium binding experiments. RESULTS： The nitro- group and amino-group of the template can interact with functional monomer MAA through hydrogen bonding or ionic interaction in ethanol solution. The molecularly polymers prepared under this condition possess obvious specific recognition ability and stereo- selectivity. CONCLUSION： The polymer is expected to be further used as the high effective adsorbents or the chiral chromatographic stationary phase for the separation of D- （ - ） - NAB.