中文摘要：

沉默信息调节因子2（silence information regulator 2,Sir2）家族是一类保守的去乙酰化酶蛋白家族,广泛存在于古细菌到哺乳动物的多种生物中,具有依赖NAD＋的去乙酰化酶和ADP-核糖转移酶活性。Sir2在染色质沉默、基因调控、代谢调节和细胞寿命调节等众多生命活动中发挥着重要作用。它主要是通过去乙酰化酶活性以及与其他蛋白相互作用从而调节染色质结构、修饰转录相关因子,实现对基因转录的调节。本文重点对Sir2参与基因转录调控的研究进展作一综述。

英文摘要：

Silence information regulator 2 （Sir2） family is a group of conserved deacetylases, widely existed in organisms from archaea to mammals, and characterized by NAD-dependent deacetylase and ADP-ribosyltransferase activi- ties. Sir2 plays an important role in various life progresses, such as chromatin silence, gene regulation, metabolic regula- tion, life span of cells and so on. Through its deacetylase activity and/or interaction with other proteins, Sir2 can regulate chromatin structure or modify transcription related factors, thus regulating the transcriptional process. This article empha- sizes on the progress of Sir2-dependent regulation of gene transcription.