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髁突矢状骨折继发颞下颌关节强直动物模型的初步建立
  • ISSN号:1001-3733
  • 期刊名称:实用口腔医学杂志
  • 时间:0
  • 页码:266-270
  • 语言:中文
  • 分类:R782.610.5[医药卫生—口腔医学;医药卫生—临床医学] R683.42[医药卫生—骨科学;医药卫生—临床医学;医药卫生—外科学]
  • 作者机构:[1]辽宁医学院附属第二医院口腔科,121001, [2]中国武装警察总医院口腔科, [3]北京大学口腔医院口腔颌面外科,121001
  • 相关基金:国家自然基金项目(编号:30572047)
  • 相关项目:髁突骨折继发颞下颌关节强直发病机制的初步研究
中文摘要:

目的:建立髁突矢状骨折继发颞下颌关节强直动物模型。方法:实验用小型猪4头。手术造成右侧髁突矢状骨折,切除部分关节盘,破坏颞骨和髁突的关节面,制动关节。术前及术后4个月测量下颌张口度,作CT检查,进行组织学分析。结果:实验动物中的2只术后4个月时张口度减小近1/2;CT显示关节窝与和髁突之间有骨痂形成;组织学证实关节窝与髁突之间被大量纤维组织占据,其中间杂有新生骨岛和骨桥。结论:初步成功建立髁突矢状骨折继发关节强直的动物模型,但可重复性有待改善。

英文摘要:

Objective:To establish an animal model of temporomandibular joint ankylosis induced by condylar sagittal fracture. Methods: Four miniature pigs were used to create experimental model. A sagittal fracture was performed from the top surface of lateral 1/3 of condylar head running downward in oblique line. Temporal and condylar articular surfaces were crushed by using drill bit, and the lateral half of disk was removed in the meanwhile. The sliding motion of joint was restricted with wire ligature between fossa and condylar head. The range of mouth opening was recorded preop- eratively and at the 4th month postoperatively. CT was taken for each to clue on image change. The harvested ankylosed tissue was histologically examined to validate the appearance of newly forming bony island or bony bridge connecting joint shores. Results : The range of mouth opening decreased by 1/2 at 4th month postoperatively in two miniature pigs. For both, callus-like image appeared on CT scan. In histological examination, irregularly distributed ossified fibrous tissue was found in the involved area. Conclusion: An animal model of condylar fracture-induced joint ankylosis is preliminarily established, but the reproducibility remains for further improved.

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期刊信息
  • 《实用口腔医学杂志》
  • 北大核心期刊(2011版)
  • 主管单位:第四军医大学
  • 主办单位:第四军医大学口腔医学院
  • 主编:赵铱民
  • 地址:西安市长乐西路145号第四军医大学口腔医院
  • 邮编:710032
  • 邮箱:j-pr-s@fmmu.edu.cn
  • 电话:029-83224470
  • 国际标准刊号:ISSN:1001-3733
  • 国内统一刊号:ISSN:61-1062/R
  • 邮发代号:52-90
  • 获奖情况:
  • 荣获陕西省1995、1999、2001年优秀科技期刊一等奖
  • 国内外数据库收录:
  • 美国化学文摘(网络版),日本日本科学技术振兴机构数据库,中国中国科技核心期刊,中国北大核心期刊(2004版),中国北大核心期刊(2008版),中国北大核心期刊(2011版),中国北大核心期刊(2014版),中国北大核心期刊(2000版)
  • 被引量:18954