中文摘要：

选取高生态学效度的科学发明问题作为实验材料,采用＂学习-测试＂的两阶段实验范式,利用静息态功能磁共振成像技术,基于局部一致性（Re Ho）和低频振幅（ALFF）的分析方法,研究科学发明问题解决的神经机制。在控制被试性别、年龄和常规性问题解决能力后,结果发现左侧前扣带回（Anterior Cingulate Cortex,ACC）的ReHo值和个体科学发明问题解决的正确率显著正相关,ALFF的结果同样印证了这一发现。结果强调了ACC在科学发明问题解决过程中的重要作用。

英文摘要：

Creativity involved every aspect of social life. Numerous brain imaging researchers had explored the activation in the brain using a myriad of creative tasks, such as divergent thinking tasks, verbal and figural creative tasks, mental imagery, the generation of creative stories and paintings. Scientific innovation was one of the most important forms of creative thinking. The cases of creation and innovation happened in the real world had been used to study the mechanism behind creativity. However, the functions of implicated brain regions remained poorly understood. The present study employed resting-state functional magnetic resonance imaging（rs-fMRI） to investigate the neural substrates for the process of the scientific innovation problem solving.In the present study, 65 scientific innovation problems were selected from the real world and divided into novel scientific innovation（NSI） problems and old scientific innovation（OSI） problems（36 NSI problems and29 OSI problems）. Each problem consisted of two parts： heuristic prototype and the corresponding question.Numerous studies showed that the heuristic prototype inspired the solution of insightful problems. The modified＂learning-test two-phase＂ paradigm was used. Specifically, we asked the subjects to learn all the heuristic prototypes one day before the experiment, and then resolve the corresponding problems randomly in the test phase of the experiment. 16 undergraduates（mean age = 21.19 ± 1.76） were enrolled in the experiment. The rs-fMRI data was acquired using Echo Planar Imaging（EPI） sequence from a 3-T Siemens Magnetom Trio scanner（Siemens Medical, Erlangen, Germany） with a 12-channel phased-array head coil housed at MRI center of Southwest University. This scanning acquired 242 volumes in 8 min and 8 sec. Brain imaging data was processed and analyzed using the REST（Resting-State fMRI Data Analysis Toolkit） toolbox to calculate Re Ho（Regional Homogeneity） and ALFF（Amplitude of Low Frequency Fluctuation）. We use