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中文摘要：
6-溴代呋喃[2,3-d]嘧啶双环核苷是合成具有显著抗病毒活性的呋喃并嘧啶双环核苷衍生物的重要中间体.该类化合物的文献制备方法合成步骤多,并需使用钯配合物作催化剂.以易得的5-甲酰基嘧啶核苷为原料,先经与四溴化碳缩合得5-（2,2-二溴乙烯基）嘧啶核苷类似物,然后在碘化亚铜催化下发生环化反应生成目标产物,不仅缩短了合成路线,而且避免了贵金属试剂的使用,是一种经济实用的新方法.
英文摘要：
6-Bromofuro[2,3-d]pyrimidine bicyclic nucleosides are the key intermediates for the preparation of novel furo[2,3-d]pyrimidine bicyclic nucleoside derivatives with remarkable antiviral potency. The literature protocol for their synthesis involves a multi-step procedure and palladium catalyst. In this paper, an economical and practical method for their preparation is developed via condensation of the easily obtainable 5-formyl pyrimidine nucleosides with carbon tetrabromide and subsequent cyclization promoted by copper iodide.
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Copper-catalyzed N- and O-arylation of Amides: Alternative Approaches to 3,4-Dihydroquinolin-2-ones,
Selective Access to 3-Cyano-1H-indoles, 9H-Pyrimido[4,5-b]indoles, or 9H-Pyrido[2,3-b]indoles throug
Synthesis of Pyrazolo[5,1？a]isoindoles and Pyrazolo[5,1？a]isoindole-3-carboxamides through One-Pot C
Synthesis of 1,2,3-Trisubstituted Indolizines, Pyrrolo[1,2-a]quinolines, and Pyrrolo[2,1-a]isoquinol
Iodine-Initiated Domino Reaction of Hepta-1,2-dien-6-yn-4-ols and Bronsted Acid Promoted Cyclization
Tandem Reaction of 3-Hydroxyhexa-4,5-allenic Esters: a Novel Access to Diversely Substituted 2H-Pyra
Tunable Synthesis of 3-Acyl-2-naphthols and 3-Substituted Isocoumarins via Jones Reagent Promoted Ca
Synthesis of cyclopentenyl and cyclohexenyl ketones via [3+2] and [4+2] annulations of 1,2-allenic k
Synthesis of Quinazolines and Tetrahydroquinazolines: Copper-Catalyzed Tandem Reactions of 2-Bromobe
One-pot Cascade Reactions of 1-Arylpenta-3,4-dien-2-ones Leading to 2-Arylphenols and Dibenzopyroano
Synthesis of 3-(4-oxo-4H-chromen-3-yl)acrylates through the tandem reaction of 3-(2-buta-2,3-dienoyl
Synthesis of substituted quinoline via copper-catalyzed one-pot cascade reactions of 2-bromobenzalde
One-pot synthesis of 12H-benzo[b]xanthen-12-ones and naphtha[2,3-b]furans from non-naphthalene subst
One-pot Sequential Reactions Featuring a Copper-catalyzed Amination Leading to Pyrido[2,1:2,3]imidaz
Synthesis of Ketones through Microwave Irradiation Promoted Metal-Free Alkylation of Aldehydes by Ac
Synthesis of Naphthalene Amino Esters and Arylnaphthalene Lactone Lignans through Tandem Reactions o
Highly Facile and Regio-selective Synthesis of Pyrazolo[1,5-a]pyrimidines via Reactions of 1,2-Allen
Synthesis of Pyrazolo(1,5-c]quinazoline Derivatives through Copper-Catalyzed Tandem Reaction of 5-(2
Synthesis of Pyrazolo[5,1-a]isoquinolines and 8-Methylenepyrazolo[5,1-a]isoindoles via Regioselectiv
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