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金催化的C—C偶联反应研究进展
  • ISSN号：0253-2786
  • 期刊名称：《有机化学》
  • 分类：O621.2[理学—有机化学;理学—化学]
  • 作者机构：[1]江南大学医药学院,无锡214122, [2]南京大学化学化工学院,南京210093
  • 相关基金：国家自然科学基金（No.21074054）和2012江苏省大学生创新训练资助项目.
作者： 张艳[1], 罗莎[1], 朱成建[2]
关键词： sp3-C—H活化, 交叉脱氢偶联, 氧化烷基化, 金催化剂, sp3-C--H activation, cross-dehydrogenative coupling, oxidative alkylation, gold catalyst
中文摘要：

以Bu4NAuCl4为催化剂，H2O2作为氧化剂，在温和的反应条件下实现了叔胺氮的邻位碳原子上sp3-C-H与硝基烷烃的氧化偶联．反应条件温和，室温、空气下即可进行，适用范围广泛，产率高，后处理方便．为新的C—C键的形成提供了一条简洁高效的反应路径，并且合成了一系列可能具有重要药理和生物活性的卢一硝基氨化合物．

英文摘要：

Activation of two sp3-C--H bonds and oxidative alkylation of sp3-C--H bond adjacent to a nitrogen atom of tertiary amine were catalyzed by Bu4NAuCl4 with H2O2 as oxidant under mild reaction conditions. The safe, convenient, and environmentally benign process, as well as the broad substrate scope, low catalyst loading, high selectivity, short reaction time, and good yields make the protocol very practical.

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期刊信息
  • 《有机化学》
  • 中国科技核心期刊
  • 主管单位:
  • 主办单位:中国化学会 中国科学院上海有机化学研究所
  • 主编：陈庆云
  • 地址：上海市枫林路354号
  • 邮编：200032
  • 邮箱：bianji@mail.sioc.ac.cn
  • 电话：021-54925244
  • 国际标准刊号：ISSN：0253-2786
  • 国内统一刊号：ISSN：31-1321/O6
  • 邮发代号:4-285
  • 获奖情况:
  • 中国期刊方阵“双效”期刊
  • 国内外数据库收录:
  • 俄罗斯文摘杂志,美国化学文摘（网络版）,荷兰文摘与引文数据库,美国科学引文索引（扩展库）,日本日本科学技术振兴机构数据库,中国中国科技核心期刊,中国北大核心期刊（2004版）,中国北大核心期刊（2008版）,中国北大核心期刊（2011版）,中国北大核心期刊（2014版）,中国北大核心期刊（2000版）
  • 被引量:14408