Gle1蛋白是一种广泛存在于真核细胞内的mRNA输出因子,是第一个被发现的含有核输出信号的细胞质蛋白。近年来的研究表明Gle1蛋白除了参与mRNA核输出外,还在蛋白质翻译过程中起重要作用。本文介绍了Gle1蛋白在mRNA核输出和蛋白质翻译过程中的双功能性。
Gle1,the first cytosolic protein identified with an nuclear export sequence(NES),is a ubiquitous mRNA export factor in the eukaryotic cells.Recent studies have showed that besides functioning in the process of mRNA exportation from the nucleus to the cytoplasm,Gle1 also plays a vital role in protein translation.The research progress of Gle1 was summarized in this paper.