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Nanomechanics of individual amyloid fibrils using atomic force microscopy
  • ISSN号:1001-6538
  • 期刊名称:Chinese Science Bulletin
  • 时间:2010.6.6
  • 页码:1608-1612
  • 分类:TB383[一般工业技术—材料科学与工程] TH742[机械工程—光学工程;机械工程—仪器科学与技术;机械工程—精密仪器及机械]
  • 作者机构:[1]Nanomaterials Laboratory, College of Sciences, Ningbo University, Ningbo 315211, China
  • 相关基金:This work was supported by the National Natural Science Foundation of China (10604034), Natural Science Foundation of Zhejiang Province (Y606309) and K. C. Wong Magna Fund in Ningbo University.
  • 相关项目:多肽在固液界面的聚集机理及其调控的研究
中文摘要:

glucagon 的压缩弹性在横向的方向的淀粉的纤丝被一条 nanoindentation 途径基于原子力量显微镜学(AFM ) 调查。与印射的力量卷,我们获得了在淀粉的纤丝,光线的压缩弹性能从被推出的放射状地应用的力量和压缩之间的关联。在纤丝的三个典型地点的估计的有弹性的模量变化了从(0.72 吗??

英文摘要:

Compression elasticity of glucagon amyloid fibrils in the transverse direction was investigated by a nanoindentation approach based on atomic force microscopy (AFM). With force-volume mapping, we obtained the correlations between radially applied force and compression of amyloid fibrils, from which the radial compressive elasticity can be deduced. The estimated elastic modulus at three typical locations of fibrils varied from (0.72±0.80) GPa to (1.26±0.62) GPa under small external forces, implying the structural heterogeneity of different fibrils.

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