中文摘要：

Hedgehog信号通路是内分泌腺体发育的一个重要调控因子通路。近年来,Desert Hedgehog（Dhh）在睾丸性腺发育中的调控作用备受关注,尤其是对Leydig细胞的调节作用。在睾丸中,Dhh由Sertoli细胞旁分泌产生而作用于Leydig细胞,对其增殖、分化过程及其分泌睾酮的功能起调控作用。睾酮的分泌对睾丸发育、精子发生及雄性表型的维持至关重要,因而对Dhh因子的正确调控是生精功能的前提条件。对睾丸中Hedgehog信号通路的研究,也将对雄激素不足及生精障碍等疾病的病理生理机制研究和临床治疗具有一定的潜在意义。

英文摘要：

Hedgehog signaling pathway plays an important role in regulating the development of endocrine glands.Desert hedgehog（Dhh） has become a recent focus for its regulation of testis development,especially of Leydig cells.Dhh,as a Sertoli cell product,regulates the proliferation and differentiation of Leydig cell lineage and functions to secrete testosterone through a paracrine signaling mechanism.Testosterone,as the most important sex hormone of the male,plays a critical role in testis development,spermatogenesis and maintenance of normal masculinization.Therefore,normal Dhh signaling pathway ensures normal spermatogenic function.Researches on the Hedgehog signaling pathway in the testis have a potential significance for studying the pathophysiological mechanisms of androgen deficiency and dyszoospermia,as well as for the clinical treatment of these diseases.