中文摘要：

育龄妇女超重和肥胖问题日渐突出,成为全球关注的健康问题。越来越多的研究显示,孕前肥胖和孕期过度增重增加子代神经发育障碍的风险,而目前对于孕前肥胖和孕期过度增重引起儿童神经发育障碍的机制还不是十分明确。新兴的研究表明,母体超重和肥胖引起的全身慢性炎症和胎盘炎症可能介导子代神经发育障碍的发生。本综述主要就孕前肥胖和孕期过度增重引起子代神经发育障碍相关的母体全身炎症和胎盘炎症进行探讨。

英文摘要：

The epidemic of overweight and obesity in women of childbearing age is outstanding and has become a global health concern. Moreover, studies have shown that pre-pregnancy obesity and excessive weight gain during pregnancy increase the risk of neurodevelopmental disorders of offspring. However, the mechanism underlying maternal overweight or obesity-induced neurodevelopmental disorders is not clear. Emerging researches suggest that systemic and placental inflammation caused by maternal overweight or obesity may mediate the occurrence of offspring neurodevelopmental disorders. This review focuses on maternal systemic and placental inflammation caused by pre-pregnancy and excessive weight gain during pregnancy, and how these inflammations result in neurodevelopmental disorders in the offspring.