中文摘要：

目的 分析癫痫致认知障碍的危险因素。方法 选取2014年4月-2015年9月入住神经内科的80例癫痫患者作为观察组,并选同期体检健康者60例作为对照组,选用美国简明精神状态检查量表（Mini-Mental State Examination,MMSE）对所有受试者进行评估,并进行危险因素分析。结果 观察组时间定向、空间定向、文字指令等各方面评分及MMSE总评分均较对照组显著降低,差异有统计学意义（P〈0.001）;相关分析结果显示,性别与认知功能障碍无相关性（P〉0.05）,而起病年龄、用药种类、癫痫类型、文化水平、发作频次均与认知功能存在明显相关性（P〈0.001）;尤以起病年龄、癫痫类型、发作频次影响最明显。结论 与健康正常人比较,癫痫患者认知功能明显下降,而起病年龄、发作频率、发作类型、用药种类均与认知功能障碍呈明显相关性。

英文摘要：

Objective To analyze risk factors for cognitive dysfunction induced by epilepsy.Methods 80 patients with epilepsy admitted to neurology department from Apri1,2014 to September,2015 were selected as observation group,and 60 healthy subjects as control group.American Mini-Mental State Examination（MMSE）was used to assess all subjects,and risk factors were analyzed. Results Compared with the control group, time orientation, spatial orientation, text instruction and oth-er aspects of scoring and MMSE total score of the observation group were significantly low-er, difference was statistically signif- icant（P 〈0.001） .Correlation analysis results show-ed that gender and cognitive dysfunction had no correlation（P 〉 0 .0 5 ） ,while onset age, drug kinds,type of epilepsy, cultural level and seizure frequency all had obvious correlation with cognitive function （P 〈 0 .0 0 1 ） ,and the onset age,type of epilepsy,seizure frequency had the most obvious affects.Conclusion Compared with healthy subjects,the cognitive function of patients with epilepsy significantly decrease,and the onset age, frequency of attack, type of epilepsy and medication types are significantly associated with cognitive dysfunction.