中文摘要：

目的建立客观的肾虚血瘀型膝骨性关节炎（KOA）肌骨模型和有限元模型，分析肾虚血瘀型KOA软骨表面应力特征。方法利用肾虚血瘀型KOA志愿者膝关节CT、MRI数据构建基于AnyBody、ANSYS软件的。肾虚血瘀型KOA肌骨模型和有限元模型，行表面肌电图（sEMG）验证并相互验证。在肾虚血瘀型KOA肌骨模型上行膝部0°、-40°、-90°、-180°运动，观察KOA膝部骨应力和应变参数，以探讨软骨表面应力特征。结果随肾虚血瘀型KOA患者从站立到下蹲过程中肾虚血瘀型KOA膝软骨表面应力大体上呈非线性递增趋势。肾虚血瘀型KOA患者膝软骨表面靠近远端应力与正常人体相比，其差异具有统计学意义（p〈0．05），而KOA患者膝软骨靠近远端应力和近端靠前侧应力与正常人间的差异无统计学意义（P〉0．05）。结论肾虚血瘀型KOA患者的膝关节软骨表面应力大体上呈非线性递增趋势，符合肾虚血瘀型KOA的临床症状特点。

英文摘要：

Objective To establish musculoskeletal model and finite element model of kidney and blood stasis type knee osteoarthritis （KOA）, and to analyze the cartilage stress characteristics of kidney and blood stasis type KOA. Methods Data from knee CT, MRI of kidney and blood stasis type KOA volunteers was used to construct musculoskeletal model and finite element model based on AnyBody and ANSYS software. Surface electromyogram （sEMG） verification and mutual verification were conducted. KOA bone stress and strain parameters were observed at the moving angles of 0°, -40°, -90°, -180° of the KOA museuloskeletal model, in order to explore the cartilage stress characteristics. Results When the positions of kidney and blood stasis type KOA patients varied from standing to squatting, the knee cartilage surface stress revealed a nonlinear increasing trend. Kidney and blood stasis KOA patient＇s knee cartilage stress near the distal end was significant different from that of normal subjects （P〈0.05）, while the KOA patient＇s knee cartilage stress near the distal end and proximal front side had no significant differences with that of normal subjects （P〉0.05）. Conclusions For kidney and blood stasis type of patients with KOA, cartilage surface stress displays a nonlinear increasing trend along with the stress concentration at the motion cartilage surface, which is consistent with the clinical features.