中文摘要：

病毒外壳蛋白(CP)是烟草花叶病毒(TMV)基因结构的重要组成部分,其主要功能除保护核酸物质不被降解外,还与TMV的远距离移动及寄主症状有关。目前研究较多的是CP基因介导的抗性、药剂干扰CP的聚合等,而有关靶标CP与药剂的作用机理尚未有系统全面的报道。从结构生物学的角度出发,详细介绍了TMVCP在电镜及单晶衍射技术下的三维结构;比较了国内已报道的CP的基因序列;综述了CP在基因工程领域的应用及其受药剂分子的干扰作用等方面的研究进展。以毒氟磷药剂为例,分析了其可能作用于TMVCP的分子机理,预测了毒氟磷小分子与TMVCP大分子可能的作用位点。有助于进一步研究和发现新型抗TMV药剂。

英文摘要：

Coat protein(CP) is an important part of the genomic structure of the tobacco mosaic virus(TMV),its main function not only includes the protection of DNA from degradation,but also has a close relationship with the TMV long-distance movement and host symptoms.Presently,the study of TMV CP mainly focus on CP-mediated resistance,interference the polymerization of CP by agent and so on,while the mechanism of agent action with target CP has not been comprehensively reported.From the perspective of structural bio...