中文摘要：

内质网（ER）是一个膜的网络,分泌型蛋白质和膜蛋白质在其中折叠、加工、成熟、储存及转运。未折叠蛋白质的集聚、营养状况的变化等均可干扰内质网稳态,产生内质网应激（ERS）,激活未折叠蛋白质应答（UPR）系统恢复ER功能的完整性。持续剧烈的ERS无法恢复时,细胞死亡程序被激活,包括细胞凋亡与自噬,清除受损细胞,维持生命进程。ERS引起的凋亡与自噬之间形成了复杂的调控网络,本文就此展开综述。

英文摘要：

The endoplasmic reticulum （ER） is a network of membrane system, where folding, processing for maturation, storage and transportation of the secretory and membrane protein take place. In some conditions, such as accumulation of unfolded protein or change of nutritional state, ER stress is provoked, and then the unfolded protein response （UPR） is activated to recover the homeostasis of ER. However, excessive ER stresses result in cell death-apoptosis and autophagy, to clear damaged cells and maintain the vital processes. Apoptosis and autophagy triggered by ERS form complex regulatory networks, which will be discussed in this review.