中文摘要：

心血管疾病是一个全球性公共健康问题。在过去几十年中,心血管病呈现出全球性快速流行趋势,原因不明。B族维生素与人体的物质和能量代谢关系密切。长期摄入过量的B族维生素对人体有何影响？未引起人们的重视。最近,我们的生态学研究结果显示,美国肥胖和糖尿病流行与人均维生素B1、B2和B3（烟酸和烟酰胺）呈显著的滞后相关关系。已有的流行病学、临床和实验室证据强烈提示,长期摄入富含B族维生素的食物,特别是维生素B3（烟酸和烟酰胺）过量,可能是增加心血管病风险的主要因素之一。

英文摘要：

Cardiovascular disease is a global health problem.In recent decades there has been an alarming increase in the prevalence of cardiovascular disease but the etiology of this increase is still obscure.Recent etiological evidence has indicated that the prevalence of obesity and type 2 diabetes（key risk factors for cardiovascular disease） is correlated with B-vitamin consumption.Numerous studies have demonstrated that niacin,a major B vitamin,can induce insulin resistance and glucose intolerance.High intake of B vitamins may thus be a risk factor for cardiovascular disease.This minireview will briefly discuss the relationship between excess B-vitamin intake and risk of cardiovascular disease.