中文摘要：

L-精氨酸是一种非常重要的半必需氨基酸，其作为生物体生成NO的前体，参与尿素循环，对人和动物均具有重要的生理功能。现阶段生产精氨酸的主流方法是微生物发酵法，因此．如何快速、高效地选育精氨酸高产菌种成为业内关注的焦点。主要对精氨酸产生菌分子育种方法的最新研究进展进行了综述，并就目前存在的问题和发展方向进行了探讨。

英文摘要：

L-Arginine, a semi-essential amino acid, has lately attracted considerable attention because the amino acid has been shown to be a precursor to nitric oxide （NO） , a key component of endothelinm-derived relaxing factor. Currently, L-arginine is primarily produced by microbial fermentation, and thus rapid and efficient breeding of arginine high-yield strains has become the focus in industry. The progress of breeding methods for arginine-produeing strains was reviewed, and the current problems and perspectives on molecular breeding methods were discussed.